Phosphorylated ADAP promotes integrin-independent adhesion by stabilizing T cell receptor-induced SLP-76 microclusters.

Lewis, Juliana.


  • Abstract: T cell activation occurs in the context of the immune synapse, a specialized adhesive junction that forms at the interface between T cells and antigen presenting cells. Signaling complexes that contain the SLP-76 adaptor protein form alongside the TCR at the immune synapse and effectively augment stable T cell contacts by activating integrins. These SLP-76 microclusters also bridge ... read more
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