Regulation of MicroRNA Biogenesis: A miRiad of mechanisms.
Davis, Brandi N.
Abstract: microRNAs are small, non-coding RNAs that influence diverse
biological functions through the repression of target genes during normal development
and pathological responses. Widespread use of microRNA arrays to profile microRNA
expression has indicated that the levels of many microRNAs are altered during
development and disease.... read moreThese findings have prompted a great deal of investigation
into the mechanism and function of microRNA-mediated repression. However, the
mechanisms which govern the regulation of microRNA biogenesis and activity are just
beginning to be uncovered. Following transcription, mature microRNA are generated
through a series of coordinated processing events mediated by large protein
complexes. It is increasingly clear that microRNA biogenesis does not proceed in a
'one-size-fits-all' manner. Rather, individual classes of microRNAs are
differentially regulated through the association of regulatory factors with the core
microRNA biogenesis machinery. Here, we review the regulation of microRNA biogenesis
and activity, with particular focus on mechanisms of post-transcriptional control.
Further understanding of the regulation of microRNA biogenesis and activity will
undoubtedly provide important insights into normal development as well as
pathological conditions such as cardiovascular disease and cancer.
Springer Open.read less
- Davis, Brandi, and Akiko Hata. "Regulation of MicroRNA Biogenesis: A miRiad of mechanisms." Cell Communication and Signaling 7, no. 1 (12, 2009): 1-22.