Assessment of Antigen-LC3T50A fusion protein for targeting of antigen to MHC Class I presentation via rerouting from autophagy to proteasome processing

Chakraborty, Anirban


  • This project explores whether fusion of a protein to a mutant form of LC3, a critical autophagy protein, can target the protein for MHC Class I presentation. Fusion to LC3 can target proteins for MHC Class II presentation, but dendritic cell MHC Class I presentation, known as cross-presentation, is desired for cancer vaccine applications. The initial project results have focused on building expertise ... read more
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