Effects of mutant cdc13 on CAG repeat fragility and instability in Saccharomyces cerevisiae.

Molina Vargas, Adrian Moises.

2018

Description
  • Repetitive DNA sequences break at a higher frequency than non-repetitive DNA sequences. In addition, the repetitive sequences are unstable, and can undergo expansions and contractions. Trinucleotide repeats are a category of repetitive DNA elements that can form secondary structures and cause many diseases. For example, expansions of (CAG)n/(CTG)n trinucleotide repeats are responsible for many neu... read more
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