Seizures rapidly impair phosphorylation-dependent regulatory mechanisms of KCC2.

Silayeva, Liliya.


  • Abstract: Status epilepticus, the development of prolonged or repetitive epileptiform activity without recovery in between, is a medical emergency. The vast majority of biomedical research applied to SE treatment has focused on targeting the GABAA receptor to promote neuronal inhibition. Little attention is given to the mechanism that establishes hyperpolarizing GABAA receptor currents in the adul... read more
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