Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos.

Levin, Michael.

Chernet, Brook T.

Fields, Chris.

2015

Description
  • In addition to the immediate microenvironment, long-range signaling may be an important component of cancer. Molecular-genetic analyses have implicated gap junctions—key mediators of cell-cell communication—in carcinogenesis. We recently showed that the resting voltage potential of distant cell groups is a key determinant of metastatic transformation and tumor induction. Here, we show in the Xenop... read more
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  • Chernet BT, Fields C and Levin M (2015) Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos. Front. Physiol. 5:519. doi: 10.3389/fphys.2014.00519.
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