Background: Chronic Fatigue Syndrome (CFS) is a neuroimmunoendocrine
disease affecting about 1% of the US population, mostly women. It is characterized by
debilitating fatigue for six or more months in the absence of cancer or other
systemic diseases. Many CFS patients also have fibromyalgia and skin hypersensitivity
that worsen with ... read morestress. Corticotropin-releasing hormone (CRH) and neurotensin (NT),
secreted under stress, activate mast cells (MC) necessary for allergic reactions to
release inflammatory mediators that could contribute to CFS
symptoms.