Corticotropin releasing factor and dopamine interactions in a heterogeneous ventral tegmental area: How can aversive experiences heighten cocaine self-administration?.

Holly, Elizabeth.


  • Abstract: Stress rapidly and potently excites certain dopamine neurons in the ventral tegmental area (VTA), promoting phasic dopamine increases in the medial prefrontal cortex (mPFC) and nucleus accumbens shell (NAcSh). Repeated stressful episodes have been linked to addiction both clinically and preclinically, so stress-induced activation of this mesocorticolimbic dopamine system may trigger long... read more
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