Pharmacokinetics of fentanyl in epileptic patients during concomitant therapy with phenytoin or carbamazepine

Ma, Zhijun.


  • Abstract: Fentanyl was first approved for clinical use in the United States in 1968, and is an opioid used for pain medication and anesthesia. Clinical studies have shown that epileptic patients treated chronically with certain antiepileptic drugs, including carbamazepine and phenytoin, have higher fentanyl requirements during maintenance of anesthesia. The hypothesis is that antiepileptic ... read more
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