An amino acid motif within the GABAA receptor alpha2 subunit promotes inhibitory synaptogenesis and seizure resilience.

Nathanson, Anna.


  • The efficacy of inhibitory neurotransmission is dependent on the accumulation of specific synaptic GABAA receptor (GABAAR) subtypes at the appropriate synaptic sites. To assess the role of a 15 amino acid motif found in the intracellular loop domain (ICD) of the GABAAR alpha2 subunit in selective inhibitory synaptogenesis, I generated a novel mouse model in which this alpha2 ICD motif has been ... read more
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