Description |
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Background: Tuberculosis, the disease due to Mycobacterium tuberculosis,
is an important cause of morbidity and mortality in the elderly. Use of mouse models
may accelerate insight into the disease and tests of therapies since mice age thirty
times faster than humans. However, the majority of TB research relies on inbred mouse
strains, ... read moreand these results might not extrapolate well to the genetically diverse
human population. We report here the first tests of M. tuberculosis infection in
genetically heterogeneous aging mice, testing if old mice benefit from
rapamycin.
Keywords: Tuberculosis, Rapamycin, HET3, DO, Diversity outbred,
Genetically diverse population, Early Secreted Antigenic Target-6
(ESAT-6).
Springer Open.read less
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Citation |
- Harrison, David, Clinton M. Astle, M. Khalid Niazi, Samuel
Major, and Gillian L. Beamer. "Genetically diverse mice are novel and valuable models
of age-associated susceptibility to Mycobacterium tuberculosis." Immunity &
Ageing 11, no. 1 (12, 2014): 1-7.
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