Helicase Requirements for Prevention of Fragility at the Flex1 AT Repeat.

Regan, Samantha B.


  • Common fragile sites are regions of the genome that are present in all individuals, and prone to breakage under replicative stress. FRA16D, one of the most highly expressed common fragile sites, is located in the WWOX gene. The WWOX protein is a putative tumor suppressor which has been linked to cancer proliferation. Flex1, an AT-rich sequence within the FRA16D site, contributes to much of FRA16D’... read more
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