Investigating the Role of Translesion Synthesis in the Prevention of CAG Repeat Fragility in S. cerevisiae.

Wu, Katherine.


  • Expansion of trinucleotide repeats, such as CAG/CTG repeats, is the cause of several neurological disorders and can result from mistakes during DNA replication and repair. These expanded CAG repeats create sites of chromosome fragility that are prone to breakage and require repair. There are several mechanisms linked to maintaining repeat fidelity, but a role for the DNA damage tolerance pathway c... read more
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