Approaches to improving in vitro engineered cardiac tissue culture using multimodal stimulation and matrix mechanobiology

Bretherton, Ross C.


  • As the leading cause of death in the world, cardiovascular disease is responsible for nearly a third of all mortality. Limited regenerative potential of adult mammalian myocardial muscle and chronic fibrosis lead to maladaptive remodeling of the left ventricle in response to changing mechanical loads, ultimately leading to heart failure. To enhance regeneration and attenuate fibrosis, tissue ... read more
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