Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation.
Arendt, Lisa M.
Briendel, Jerrica L.
Lyle, Stephen R.
Naber, Stephen P.
Jay, Daniel G.
Introduction: The prognosis of breast cancer is strongly influenced by
the developmental stage of the breast when the tumor is diagnosed.
Pregnancy-associated breast cancers (PABCs), cancers diagnosed during pregnancy,
lactation, or in the first postpartum year, are typically found at an advanced stage,
are more aggressive and have a poor... read moreer prognosis. Although the systemic and
microenvironmental changes that occur during post-partum involution have been best
recognized for their role in the pathogenesis of PABCs, epidemiological data indicate
that PABCs diagnosed during lactation have an overall poorer prognosis than those
diagnosed during involution. Thus, the physiologic and/or biological events during
lactation may have a significant and unrecognized role in the pathobiology of
Keywords: adipose stromal cells, adipose stromal cells derived from involuting mammary glands, adipose stromal cells derived from lactating mammary glands, adipose stromal cells derived from nulliparous mammary glands, adipose stromal cells derived from pregnant mammary glands, adipose stromal cells derived from regressed mammary glands, bovine serum albumin, carcinoma-associated fibroblast, carcinoma-associated fibroblast-like, conditioned media, cellular retinoic acid binding protein 1, 4′,6-diamidino-2-phenylindole, (Dulbecco's) modified Eagle's medium, fatty acid binding protein 4, gene set enrichment analysis, hemotoxylin and eosin, hormone sensitive lipase, human umbilical cord endothelial cell, interleukin 6, Krupple-like factor 2, mouse heart endothelial cell, matrix metalloproteinase 9, non-obese diabetic severe combined immunodeficient, pregnancy-associated breast cancers, phosphate-buffered saline, platelet-derived growth factor C, placental-like growth factor, peroxisome proliferator-activated receptor gamma, preadipocyte factor 1, Penicillan/Streptomycin, Fungicide, Reduction mammoplasty adipose, reverse transcriptase polymerase chain reaction, stem cell antigen 1, standard error of the mean, small hairpin CRABP1, small hairpin scrambled, thyroid response element, vascular endothelial growth factor A, vascular endothelial growth factor C, vascular endothelial growth factor D.
Springer Open.read less
- McCready, Jessica, Lisa M. Arendt, Eugene Glover, Vandana Iyer, Jerrica L. Briendel, Stephen R. Lyle, Stephen P. Naber, Daniel G. Jay, and Charlotte Kuperwasser. "Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation." Breast Cancer Research 16, no. 0 (2, 2014): 1-19.