pH-mediated electronic wound dressing for controlled drug delivery
administration of drugs in a timely controlled manner according to the physiological
needs can enhance the healing process in chronic wounds. Here a pH-mediated electronic
wound patch is presented. This smart patch is capable of pH-based active drug release
where the pH of the patch was itself controlled electronically. The wound patch is
comprised of electrodes coated with ... read morea PEGDA/Laponite hydrogel layer containing chitosan
nanoparticles (CHPs) as drug carriers. The engineered patch is pH responsive and enables
the on-demand release of drug by electronically adjusting the pH. Applying electrical
voltage between working and reference electrodes triggers charged ions and a consequent
pH change. In basic pH, the CHPs were stimulated and drugs were released while in acidic
pH the release profile was negligible. The pH shifting implemented by electrical voltage
would not affect the pH of the wound site and its biocompatibility was confirmed in this
study. This platform can provide precise control over administration of drug in order to
improve the therapeutic effectiveness while reduce the side effects of the
Thesis (M.S.)--Tufts University, 2017.
Submitted to the Dept. of Biomedical Engineering.
Advisors: Sameer Sonkusale, and Qiaobing Xu.
Committee: Xiaocheng Jiang, and Sergio Fantini.
Keyword: Biomedical engineering.read less