%0 PDF
%T Exponential time differencing for hodgkin-huxley-like ODEs.
%A Börgers, Christoph.; Nectow, Alexander.
%D 2018-04-05T10:20:46.473-04:00
%8 2018-04-05
%I Tufts University. Tisch Library.
%R http://localhost/files/rn301c46f
%X Several authors have proposed the use of exponential time differencing (ETD) for Hodgkin-Huxley-like partial and ordinary differential equations (PDEs and ODEs) For Hodgkin- Huxley-like PDEs, ETD is attractive because it can deal effectively with the stiffness issues that diffusion gives rise to. However, large neuronal networks are often simulated assuming spaceclamped neurons, i.e., using the Hodgkin-Huxley ODEs, in which there are no diffusion terms. Our goal is to clarify whether ETD is a good idea even in that case. We present a numerical comparison of first-and second-order ETD with standard explicit time-stepping schemes (Euler's method, the midpoint method, and the classical fourth-order Runge-Kutta method) We find that in the standard schemes, the stable computation of the very rapid rising phase of the action potential often forces time steps of a small fraction of a millisecond. This can result in an expensive calculation yielding greater overall accuracy than needed. Although it is tempting at first to try to address this issue with adaptive or fully implicit time-stepping, we argue that neither is effective here. The main advantage of ETD for Hodgkin-Huxley-like systems of ODEs is that it allows underresolution of the rising phase of the action potential without causing instability, using time steps on the order of one millisecond. When high quantitative accuracy is not necessary and perhaps, because of modeling inaccuracies, not even useful, ETD allows much faster simulations than standard explicit time-stepping schemes. The second-order ETD scheme is found to be substantially more accurate than the first-order one even for large values of δt. © 2013 Society for Industrial and Applied Mathematics.
%[ 2018-10-10
%9 Text
%~ Tufts Digital Library
%W Institution