Regulation and function of endothelial cell mineralocorticoid receptor in cardiovascular physiology and pathology.

Barrett Mueller, Katelee.


  • Abstract: The steroid hormone aldosterone activates the mineralocorticoid receptor (MR), a steroid receptor transcription factor that contributes to cardiovascular disease. While MR is best known for its role in enhancing sodium and water reabsorption in the renal epithelia to increase blood volume, clinical trials have demonstrated benefit for MR antagonism disproportionate to its antihypertensiv... read more
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