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One of the major problems in tissue engineering that has still to be resolved is the ability to promote vasculogenesis in artificial tissue. Without this capability, tissue thickness is severely limited, preventing the tissue from being used as a therapeutic. Several attempts have been made to overcome the problem, but a more biomimetic approach is required before these systems will work. Previous ... read moresystems have relied on bolus administrations of growth factors or by delivering a single growth factor from a homogenous scaffold. Results have shown that these methods are unsatisfactory, and a more biomimetic approach is required before these systems will work. More recent attempts, aimed at delivering multiple growth factors from highly engineered scaffolds have shown promise, and this investigation is part of the new wave of vasculogenic systems.read less
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