Mixed Lineage Kinase 3 (MLK3) functions as a cGMP-dependent protein kinase I alpha (PKGI) substrate and inhibits cardiac remodeling in vivo

Blanton, Robert.


  • Abstract: Protein kinase G I (PKGI) prevents cardiac hypertrophy and dysfunction in the failing heart. Although PKGI-activating drugs remain under investigation for the treatment of heart failure, the downstream molecular substrates through which PKGI regulates these processes remain incompletely understood. In this study we identified one candidate PKGIα substrate in the myocardium, Mixed ... read more
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