Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program.
Background/Objectives: Low vitamin D status, assessed by blood 25-hydroxyvitamin D
(25OHD) level, has been associated with cardiometabolic disease. However, results are
inconsistent, there are no data in a multi-ethnic population representative of those at
risk for cardiometabolic disease and there are limited reports on the association
between 25OHD and non-traditional components o... read moref metabolic syndrome. The objective of the
study was to investigate the association of 25OHD with metabolic syndrome, its
individual components, and markers of beta cells secretion and insulin sensitivity in a
population at risk for diabetes. Subjects/Methods: In a cross-sectional analysis using
baseline data from the placebo and lifestyle intervention arms of the Diabetes
Prevention Program (DPP) (N=2040), multivariate logistic regression models were built to
estimate the odd ratios and 95% confidence interval for having metabolic syndrome and
for each of its individual components across 25OHD tertiles. Multivariate linear
regression models were built to estimate the adjusted mean difference of insulin
secretion and sensitivity according to 25OHD tertiles. Results: After multivariate
adjustment, participants in the highest tertile of vitamin D (median 25OHD concentration
30.6 ng/mL) had a lower odds of prevalent metabolic syndrome (odds ratio 0.62; 95%CI
0.45; 0.84) compared to participants in the lowest tertile (median 25OHD concentration
12.1 ng/mL). Those in the highest tertile of vitamin D status had smaller waist
circumference, higher high-density lipoprotein, and lower fasting plasma glucose. Higher
plasma 25OHD concentration was associated with higher insulin sensitivity and lower
insulin secretion and no difference in disposition index. Conclusion: In a multi-ethnic
population at high risk for diabetes and cardiovascular disease, higher plasma 25OHD
concentration was inversely associated with prevalent metabolic
Thesis (M.S.)--Tufts University, 2012.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Anastassios Pittas.
Committee: David Kent, and Robin Ruthazer.
Keywords: Medicine, and Epidemiology.read less