Activity-Dependent Phosphorylation of the Transcription Factor Sp4: Role in Development and Disease.

Saia, Gregory.


  • Abstract: The formation of a functional nervous system requires the activity of cell extrinsic cues that promote cell differentiation and development by influencing intrinsic gene expression programs. The transcription factor Sp4 is expressed in neurons where it controls the developmental patterning of dendrites. Alterations of the Sp4 gene have been linked to schizophrenia and bipolar disorder (B... read more
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