Aging alters transcriptional circuitries and SLUG-mediated cellular states of mouse mammary epithelium.

Gross, Kayla.


  • Age-associated decline in stem cell function predisposes tissues to dysfunction and disease and is driven by disruption of cellular homeostasis. The bulk of age-associated changes to the mammary epithelial epithelium and its stem/progenitor compartments have been studied after the onset of reproductive senescence (menopause) that occurs around midlife, yet nearly half of women in the U.S. are ... read more
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