| Description |
-
Abstract:
Schizophrenia has been likened to the 'cancer of mental health' due to the severe
domestic and global burden of morbidity and mortality that it imposes. The side effect
profile of antipsychotic treatments—as well as high rates of treatment
non-adherence due to functional impairment from the disease, and other factors—is
a barrier to improved clinical outcome for many individuals with ... read moreschizophrenia.
Familiar routes of drug delivery that capitalize on existing habitual behaviors - such
as the high prevalence of nicotine dependence in this population (78-88% in
schizophrenia vs 22.5% the general population - may offer a unique approach to improving
treatment adherence in this population. In this project, the technical feasibility of
therapeutically delivering an antipsychotic medication by inhalation was explored and
assessed. These studies demonstrate the technical feasibility of administering a
clinically relevant antipsychotic drug via electronic-cigarettes, opening new avenues to
increase patient adherence and improve clinical
outcomes.
Thesis (M.S.)--Tufts University,
2018.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Anthony
Barry.
Committee: David Kaplan, and Mark
Cronin-Golomb.
Keyword: Biomedical
engineering.read less
|
|---|
This object is in collection
