Abstract: Coherent Hemodynamics Spectroscopy (CHS) is a novel technique based on quantitative relationships between cerebral hemodynamic oscillations and relevant physiological parameters like cerebral blood volume (CBV), cerebral blood flow (CBF), and metabolic rate of oxygen (CMRO2). A crucial aspect for the optimal application of CHS is the implementation of pertinent experimental protocols, wi... read moreth the focus being on eliciting Coherent cerebral hemodynamic oscillations. This work focusses on modifications implemented on existing CHS protocols, to uncover optimal Pneumatic-Cuff based experimental conditions. Results of this study involved examining features of the oscillations suitable for CHS, like the Phase Synchronization Index (PSI), which serves as a measure of coherence. It was found that certain Pneumatic-Cuff pressures and positions elicited optimally Coherent cerebral hemodynamic oscillations compared to others. A statistical test was applied to further check the significance of obtained results.