Overcoming natural replication barriers: differential helicase requirements

Freudenreich, Catherine H.

Anand, Ranjith P.

Shah, Kartik A.

Niu, Hengyao

Sung, Patrick

Mirkin, Sergei M.


  • DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication across these barriers, we analyzed fork progression through them in wild-type and mutant yeast cells, using 2-dimensional gel-electrophoretic analysis of the replication intermediates. ... read more
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