| Description |
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Background: The p6 region of the HIV-1 structural precursor polyprotein,
Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1
and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 and the ESCRT
adaptor Alix, respectively, and are critical for efficient budding of virus particles
from the plasma ... read moremembrane. L domain-2 is thought to be functionally redundant to PTAP.
To identify possible other functions of L domain-2, we examined this motif in
dominant viruses that emerged in a group of 14 women who had detectable levels of
HIV-1 in both plasma and genital tract despite a history of current or previous
antiretroviral therapy.
Keywords: HIV Gag, HIV protease, Protease inhibitors, Late domain,
Anti-retroviral drugs, ESCRT.
Springer Open.read less
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This object is in collection
| Citation |
- Watanabe, Susan, Viviana Simon, Natasha D. Durham, Brittney R.
Kemp, Satoshi Machihara, Kimdar Sherefa Kemal, Binshan Shi, Brian Foley, Hongru Li,
Benjamin K. Chen, Barbara Weiser, Harold Burger, Kathryn Anastos, Chaoping Chen, and
Carol A. Carter. "The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or
ART)-exposed individuals influences protease inhibitor susceptibility." Retrovirology
13, no. 1 (12, 2016): 1-14.
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