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Abstract: Psychiatric disorders, such as depression and other mood disorders, have a high comorbidity with drug use disorders. Research has led to the study of the mesolimbic dopaminergic pathway as a key site for the comorbidity of the two diseases because chronic stress and drug abuse alter dopamine (DA) release in a similar manner. Two different intensities of social defeat stress, brief or ... read moremoderate, can be used as a model to induce depressive-like symptoms and study the alterations of the DAergic system by examining the behavioral effects, the changes in DA in the nucleus accumbens in response to an amphetamine injection, as well as cocaine taking behavior. Male mice were exposed to ten days of social defeat stress, with behaviors during the defeats analyzed from days 1 and 10, and then either took part in in vivo microdialysis or cocaine self-administration. Stressed mice show an increased change in DA in response to a d-amphetamine challenge, with moderately stressed mice showing a longer-lasting effect. Stressed mice also take more cocaine on an FR schedule and briefly stressed mice display defensive behaviors more frequently than moderately stressed mice. The intensities of social defeat stress can produce distinct effects on DA, drug taking, and behavior.read less
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