Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of intermittent social defeat stress in rats.

Holly, Elizabeth.


  • Abstract: Brief episodes of social stress can result in cross-sensitization to cocaine in rodents, characterized by augmented locomotor activation, dopamine (DA) levels in the nucleus accumbens (NAc), and cocaine taking during a 24 hour "binge" in male rats. However, females are more vulnerable than males at each phase of cocaine addiction, and while these sex differences have been replicated ... read more
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