Critical roles for somatic hypermutation and TLR signaling in the development of B cell central tolerance.

McDonald, Gabrielle.


  • Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with a strong female bias. SLE pathogenesis is largely mediated by autoantibodies that form immune complexes, deposit in tissues, and cause inflammation. Autoantibody production is thought to be the result of somatic hypermutation (SHM) of Ig genes in antigen-activated B cells in the germinal center. However, we have ... read more
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