Persistent increase of I.V. cocaine self-administration in a subgroup of C57BL/6J male mice after intermittent and continuous social defeat stress
Arena, Danielle.
2019
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Stressful life experiences can persistently increase the motivation
for, and consumption of, intensely rewarding stimuli, like cocaine over time. In
rodents, intermittent versus continuous exposure to social stress engender
opposing changes to reward-related behavior, as measured by consumption of sucrose
and cocaine. The present study examines if the effects of intermittent versus
continuous ... read moresocial stress on cocaine self-administration in mice parallel those
seen in rats. Both forms of social stress involve a brief daily physical
confrontation with an aggressive resident for 10 consecutive days. Continuous
social stress involves constant visual and olfactory exposure to an aggressive
resident via habitation in a protected portion of the resident's home cage, while
exposure to an aggressive resident during intermittent social stress is limited to
a single, physical encounter per day. Implementing a femoral vein catheterization
method for the first time in mice, we determined divergent changes to intravenous
cocaine self-administration. Modestly increased cocaine self-administration after
intermittent social stress was confirmed. In a subset of animals, continuous
social stress in mice substantially increased cocaine self-administration and
sucrose intake. By stark contrast, another subpopulation displayed attenuation of
cocaine self-administration and sucrose intake after continuous social stress.
Bimodal divergence in responding for rewarding stimuli including cocaine after
social stress experience likely reflects two opposing forms of coping to
continuous social stress that are based on discrete neural
activity.
Thesis (M.S.)--Tufts University, 2019.
Submitted to the Dept. of Psychology.
Advisor: Klaus Miczek.
Committee: Joseph DeBold, and Robert Bridges.
Keywords: Psychobiology, Behavioral sciences, and Neurosciences.read less - ID:
- qr46rc87d
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