Calpain-1 Contributes to Platelet Hyperactivity and Pain Sensitivity in a Humanized Mouse Model of Sickle Cell Disease.

Nwankwo, Jennifer.

2016

Description
  • Abstract: Sickle cell disease (SCD) was the first genetic disorder for which a molecular mechanism was identified. SCD is caused by a glutamic acid to valine substitution in the sixth codon of the beta-globin gene, resulting in sickle hemoglobin, which polymerizes under low oxygen conditions to form sickle red blood cells (sRBCs). Reduced deformability of sickle RBCs contributes to blood vessel oc... read more
This object is in collection Corporate name Permanent URL
ID:
qf85np58z
Component ID:
tufts:20480
To Cite:
DCA Citation Guide    EndNote