| Description |
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Background: Integration of retroviral DNA into a germ cell may lead to a
provirus that is transmitted vertically to that host's offspring as an endogenous
retrovirus (ERV). In humans, ERVs (HERVs) comprise about 8% of the genome, the vast
majority of which are truncated and/or highly mutated and no longer encode functional
genes. The most ... read morerecently active retroviruses that integrated into the human germ line
are members of the Betaretrovirus-like HERV-K (HML-2) group, many of which contain
intact open reading frames (ORFs) in some or all genes, sometimes encoding functional
proteins that are expressed in various tissues. Interestingly, this expression is
upregulated in many tumors ranging from breast and ovarian tissues to lymphomas and
melanomas, as well as schizophrenia, rheumatoid arthritis, and other
disorders.
Keywords: evolution, endogenous retroviruses, human
genome.
Springer Open.read less
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| Citation |
- Subramanian, Ravi, Julia H. Wildschutte, Crystal Russo, and
John M. Coffin. "Identification, characterization, and comparative genomic
distribution of the HERV-K (HML-2) group of human endogenous retroviruses."
Retrovirology 8, no. 3 (12, 2011): 1-22.
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