Regulation of the translocation efficiency of Icm/Dot translocated substrates by protein conformation.

Amyot, Whitney.


  • Abstract: Legionella pneumophila uses a type 4B secretion system known as the Icm/Dot system to deliver over 200 effector proteins to the host cell for the establishment and maintenance of a replication vacuole. Translocation of a large majority of these Icm/Dot translocated substrates (IDTS) is facilitated by the Icm/Dot adapter complex IcmS/W. The characteristics of translocation competence for ... read more
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