The Association of Omega-3 Fatty Acids and Cardiovascular Outcomes in Patients with Acute Coronary Syndrome.
Ortiz, Ronnie.
2013
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Abstract:
Cardioprotective associations have been seen with omega-3 fatty acids, specifically the
omega-3 index which is the sum of eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) fatty acid fractions inside the red blood cell and to a lesser extent with serum
omega-3 fatty acid levels. However, the association of omega-3 fatty acids in acute
coronary syndromes (ACS) is less establ... read moreished. We conducted a retrospective cohort study
of patients with ACS who participated in the biological mechanism cohort of the
IMMEDIATE Trial. We first examined the relationship of omega-3 index on the composite
outcome of cardiac arrest, or mortality or hospitalization for heart failure within 30
days. Second we looked at the relationship of omega-3 index and 30-day infarct size.
Third, we evaluated the effects GIK has on changes in EPA and DHA fractions in the serum
over the 12 hour treatment period. Fourth, using the initial blood sample, we checked
the correlation of the summed EPA plus DHA fractions in the serum and with the
corresponding summed fractions from the red blood cell (omega-3 index). Using survival
analysis, there was no significant association between the omega-3 index and our
composite outcomes at 30-days (HR 0.78, 95% CI 0.48-1.26). Spearman's Rank correlation
test showed no association between omega-3 index and infarct size, rho=0.02, p=0.82. The
use of GIK, compared to placebo, was associated with significantly higher mean serum EPA
at the first two evaluation periods of infusion (initial: p<0.01, 6 hours: p<0.01,
12 hours: p=0.06). Mean serum DHA was higher in GIK versus placebo at all time points,
but failed to reach significance at an adjusted alpha of 0.017 (initial: p=0.35, 6
hours: p=0.03, 12 hours: p=0.38). A positive correlation was found between the sum of
serum EPA plus DHA with omega-3 index, rho 0.50, p<0.01. Among participants with ACS
the omega-3 index was not significantly associated with our composite outcome. GIK had a
significant effect on changes over time in serum EPA but not on DHA. There was a
significant correlation between summed EPA and DHA fractions measured in the serum and
in the omega-3 index.
Thesis (M.S.)--Tufts University, 2013.
Submitted to the Dept. of Clinical & Translational Science.
Advisor: Harry Selker.
Committee: Harry Selker, Joni Beshansky, and Robin Ruthazer.
Keywords: Medicine, Public health, and Nutrition.read less - ID:
- pz50h764q
- Component ID:
- tufts:20483
- To Cite:
- DCA Citation Guide EndNote
