An investigation of the role that peptidoglycan composition and remodeling plays in the release of pneumolysin from Streptococcus pneumoniae.

Greene, Neil.


  • Abstract: Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium that asymptomatically colonizes the human nasopharynx and is also a causative agent of several invasive diseases. Pneumolysin (Ply) is a conserved virulence factor belonging to the cholesterol-dependent cytolysin family of pore-forming toxins that is necessary for both commensal and pathogenic lifestyles of this org... read more
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