Social Stress Modulations of Accumbal Dopamine during Extended Cocaine Binge.
Dawes, Monica H.
- Rationale: Increased vulnerability to drug abuse, specifically cocaine abuse, is associated with repeated exposure to stressful events, both in clinical populations and in animal models of drug abuse. Stressful experiences are hypothesized to induce long term neuroadaptations within dopamine rich circuitry which influences physiological and behavioral response to drug exposure. Objective: To exami... read morene factors that contribute to the maintenance and termination of extended bouts of cocaine intake, and the extent to which altered dopaminergic response to cocaine may promote sustained bingeing in defeat-experienced rats.Conclusions: These preliminary data offer some insight into potential stress induced differences in mesolimbic DA transmission during extended cocaine binge. Disparity in tonic extracellular DA lends some support to the DA deficiency hypothesis of addiction. However, defeat-experienced animals may also retain DA terminal function following prolonged cocaine exposure, which may facilitate extended bouts of self-administration. Further research is necessary to clarify these potential mechanisms by which stress experience potentiates escalated drug use, and perhaps, a vulnerability towards cocaine use disorder.read less