| Description |
-
Introduction: Although stem cell therapy is a promising treatment for
myocardial infarction, the minimal functional improvements observed clinically limit
its widespread application. A need exists to maximize the therapeutic potential of
these stem cells by first understanding what factors within the infarct
microenvironment affect their ... read moreability to regenerate the necrotic tissue. In this
study, we assessed both differentiation capacity and paracrine signaling as a
function of extracellular matrix remodeling after myocardial
infarction.
Keywords: Protein kinase B, ammonium persulfate, cardiac fibroblast,
cardiovascular disease, enhanced chemiluminescence, extracellular matrix, fibroblast
growth factor 2, heart failure, hepatocyte growth factor, insulin-like growth factor,
interleukin 10, liquid chromatography-tandem mass spectroscopy, myocardial
infarction, mesenchymal stem cell, N-hydroxysuccinimide, polyacrylamide,
phosphate-buffered saline, platelet-derived growth factor β, placental growth factor,
stromal cell-derived factor 1, sodium dodecylsulfate, second harmonic generation,
Tris-buffered saline and 10% tween 20, tissue culture plastic, transforming growth
factor-β receptor II, tumor necrosis factor-α, two-photon excited fluorescence,
vascular endothelial growth factor.
Springer Open.read less
|
|---|
This object is in collection
| Citation |
- Sullivan, Kelly, Kyle Patrick Quinn, Katherine Michele Tang,
Irene Georgakoudi, and Lauren Deems Black. "Extracellular matrix remodeling following
myocardial infarction influences the therapeutic potential of mesenchymal stem
cells." Stem Cell Research & Therapy 5, no. 6 (3, 2014):
1-16.
|
|---|
