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Wound healing in mammals is a complex biological process whose main goals are to close the wound quickly, inhibit blood loss, and fight infection. The skin left after a wound healing process will never achieve the same level of functionality or tensile strength as undamaged tissue. In contrast to mammalian models, the wound response observed in some amphibian species results in the replication of ... read morefully functional tissue. The goal of this study was to induce, through the application of external stimuli, a regenerative response in mammals to mimic that of regenerative species and provide a new technology for wound care. This study developed a 3D in vitro skin model in which the effects of applied electric fields and membrane potential altering solutions on improved wound healing were assessed. An electrode system was designed to measure relevant electrical properties of the model and histology and wound closure rates were analyzed as parameters for improved wound healing after treatment. Preliminary results proved the model to be effective for the testing of these parameters. Further optimization of these treatments could provide an effective new wound care technology that uses the body_�_s own machinery to provide a simple, yet complete healing of the wound.read less
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