Fishing for answers: Investigating Fibrodysplasia Ossificans Progressiva using a novel adult zebrafish model

LaBonty, Melissa.

2018

Description
  • Abstract: Fibrodysplasia Ossificans Progressiva (FOP) is a rare, autosomal dominant genetic disorder in humans characterized by the gradual ossification of fibrous tissues, including skeletal muscle, tendons, and ligaments. In humans, activating mutations in the Type I BMP/TGFβ family member receptor, ACVR1, are associated with FOP. Zebrafish acvr1l, previously known as alk8, is the functional... read more
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