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Cardiovascular disease is the leading cause of death in US, has recently become the leading cause of death in the world as well • During a myocardial infarction (heart attack), over 25% of the heart’s cardiomyocytes (muscle cells) can die in only a few hours • Scar formation post-infarct is initially beneficial, but leads to a cascade of compensatory mechanisms that eventually lead to Heart Failure ... read more(HF) and subsequently death • There is a dire need for CVD treatments that are regenerative, allowing for the in vivo replacement of damaged tissue • Realistic in vitro heart tissue models play a key role in elucidating cellular responses to the altered electrical and mechanical environment of diseased tissue. Submitted in partial fulfillment of the grant requirement of the Tufts Summer Scholars Program.read less
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