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Abstract: Tendon
injury occurs frequently, and is characterized by limited healing and scar tissue
formation, leading to increased interest in tendon tissue engineering. This work focuses
on two different needs within that field. First, there is a need for the development of
an effective system for even cell delivery to nanofiber scaffolds. Coaxial
electrospinning has shown promise as a delivery ... read moremethod for both cells and drugs, and the
first project outlined here describes the development and characterization of a coaxial
electrospinning system, with the goal of using it for these applications. Second, there
is a need for characterization of the effects of mechanical and biochemical cues known
to be tenogenic in vivo, on tendon progenitor cells in vitro. This project explores the
individual and combined effects that these cues have on tenogenic gene expression, with
the ultimate goal of understanding and furthering the ability to direct tenogenesis in
vitro.
Thesis (M.S.)--Tufts University,
2011.
Submitted to the Dept. of Biomedical
Engineering.
Advisor: Catherine
Kuo.
Committee: Qiaobing Xu, and Pamela
Yelick.
Keyword: Biomedical
engineering.read less
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