Transdermal Delivery of Biomacromolecules using Lipid-Like Nanoparticles.
Bello, Evelyn.
2015
-
Abstract: The
transdermal delivery of biomacromolecules, including proteins and nucleic acids, is
challenging, owing to their large size and the penetration-resistant nature of the
stratum corneum. Thus, an urgent need exists for the development of transdermal delivery
methodologies. This research focuses on the use of cationic lipid-like nanoparticles
(lipidoids) for the transdermal delivery ... read moreof proteins, and establishes an in vitro model
for the study. The lipidoids used were first combinatorially designed and synthesized;
afterwards, they were employed for protein encapsulation in a vesicular system. A skin
penetration study demonstrated that lipidoids enhance penetration depth in a pig skin
model, overcoming the barrier that the stratum corneum presents. This research has
successfully identified active lipidoids capable of efficiently penetrating the skin;
therefore, loading proteins into lipidoid nanoparticles will facilitate the transdermal
delivery of proteins. Membrane diffusion experiments were used to confirm the results.
This research has confirmed that lipidoids are a suitable material for transdermal
protein delivery enhancement.
Thesis (M.S.)--Tufts University, 2015.
Submitted to the Dept. of Biomedical Engineering.
Advisor: Qiaobing Xu.
Committee: Ayse Asatekin, and Sameer Sonkusale.
Keywords: Biomedical engineering, and Nanoscience.read less - ID:
- p8419055x
- Component ID:
- tufts:21358
- To Cite:
- TARC Citation Guide EndNote
