Using CRISPR-Cas9 to Study the Effect of Repeat Variation on Azf1p

Parmenter, Mackenzie L.


  • Proteins containing repeat regions are coded for by DNA that is inherently unstable and genetic variation within these regions can alter protein function. This thesis examines a new way of creating these genomic repeat variants for experimental purposes by using CRISPR-Cas9 and allowing error in double stranded break repair mechanisms to create variants. My sequencing data indicates that cutting ... read more
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