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Alcohol has long been recognized as a problematic drug. A specific population shows heightened aggression after alcohol intake. In this experiment, we looked at the effects of microinjections of GABAA and GABAB agonists and antagonists in the dorsal raphe nucleus on alcohol heightened aggression. We found that the GABAB agonist, baclofen heightened aggression in both water and ethanol self- ... read moreadministration conditions while the GABAA agonist, muscimol showed a trend of heightening aggression in the ethanol self- administration condition. The GABAA antagonist bicuculline showed overall inhibitory effects. Our findings suggest that the GABAA receptors in the dorsal raphe nucleus play a role in alcohol heightened aggression whereas the GABAB receptors do not.read less
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