Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model.

Sen, Sabyasachi.

Domingues, Cleyton C.

Rouphael, Carol.

Chou, Cyril.

Kim, Chul.

Yadava, Nagendra.

2015

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  • Introduction: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into fat, muscle, bone and cartilage cells. Exposure of subcutaneous abdominal adipose tissue derived AD-MSCs to high glucose (HG) leads to superoxide accumulation and up-regulation of inflammatory molecules. Our aim was to inquire how HG exposure ... read more
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  • Sen, Sabyasachi, Cleyton C. Domingues, Carol Rouphael, Cyril Chou, Chul Kim, and Nagendra Yadava. "Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model." Stem Cell Research & Therapy 6, no. 1 (12, 2015): 1-14.
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