| Description |
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Background: Postprandial lipemia (PPL) is likely a risk factor for
cardiovascular disease but these changes have not been well described and
characterized in a large cohort. We assessed acute changes in the size and
concentration of total and subclasses of LDL, HDL, and VLDL particles in response to
a high-fat meal. Participants (n = 1048) ... read morefrom the Genetics of Lipid-Lowering Drugs
and Diet Network (GOLDN) Study who ingested a high-fat meal were included in this
analysis. Lipids were measured at 0 hr (fasting), 3.5 hr, and 6 hr after a
standardized fat meal. Particle size distributions were determined using nuclear
magnetic resonance spectroscopy. Analyses were stratified by baseline triglycerides
(normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein
subclasses was assessed using repeated measures ANOVA.
Keywords: postprandial lipemia, lipoprotein particles, NMR, high-fat
meal.
Springer Open.read less
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| Citation |
- Wojczynski, Mary, Stephen P. Glasser, Albert Oberman, Edmond
K. Kabagambe, Paul N. Hopkins, Michael Y. Tsai, Robert J. Straka, Jose M. Ordovas,
and Donna K. Arnett. "High-fat meal effect on LDL, HDL, and VLDL particle size and
number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an
interventional study." Lipids in Health and Disease 10, no. 1 (12, 2011):
1-11.
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