Proteasome and VCP inhibition blocks necroptosis in HT-29 cells

Gurol, Kerem.


  • Abstract: Necroptosis is a programmed form of cell death mediated by the formation of a detergent-insoluble protein complex called necrosome. Receptor Interacting Protein Kinases (RIPK) 1 and 3 have been identified as the key components of the necrosome. Phosphorylation and ubiquitination of several RIPK1/3 residues have been implicated to play important roles in regulating apoptosis and necroptos... read more
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