Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy.

Kearney, Mary F.

Anderson, Elizabeth M.

Coomer, Charles.

Smith, Luke.

Shao, Wei.

Johnson, Nicholas.

Kline, Christopher.

Spindler, Jonathan.

Mellors, John W.

Coffin, John M.

Ambrose, Zandrea.

2015

Description
  • Background: Determining the anatomic compartments that contribute to plasma HIV-1 is critical to understanding the sources of residual viremia during combination antiretroviral therapy (ART). We analyzed viral DNA and RNA populations in the plasma and tissues from macaques infected with SIV containing HIV-1 RT (RT-SHIV) to identify possib... read more
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  • Kearney, Mary, Elizabeth M. Anderson, Charles Coomer, Luke Smith, Wei Shao, Nicholas Johnson, Christopher Kline, Jonathan Spindler, John W. Mellors, John M. Coffin, and Zandrea Ambrose. "Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy." Retrovirology 12, no. 1 (12, 2015): 1-17.
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