| Description |
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Background: Determining the anatomic compartments that contribute to
plasma HIV-1 is critical to understanding the sources of residual viremia during
combination antiretroviral therapy (ART). We analyzed viral DNA and RNA populations
in the plasma and tissues from macaques infected with SIV containing HIV-1 RT
(RT-SHIV) to identify possible ... read moresources of persistent viremia and to investigate the
effect of ART on viral replication in tissues. Tissues were collected at necropsy
from four pigtailed macaques infected for 30 weeks with a diverse population of
RT-SHIV. Two animals (6760 and 8232) were untreated and two animals (8030 and 8272)
were treated with efavirenz, tenofovir, and emtricitabine for
20 weeks.
Keywords: RT-SHIV, SIV or HIV evolution, HIV diversity, Single genome
sequencing (SGS), Nonhuman primate model, Antiretroviral therapy, HIV
compartmentalization, HIV persistence, SIV or HIV reservoir.
Springer Open.read less
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This object is in collection
| Citation |
- Kearney, Mary, Elizabeth M. Anderson, Charles Coomer, Luke
Smith, Wei Shao, Nicholas Johnson, Christopher Kline, Jonathan Spindler, John W.
Mellors, John M. Coffin, and Zandrea Ambrose. "Well-mixed plasma and tissue viral
populations in RT-SHIV-infected macaques implies a lack of viral replication in the
tissues during antiretroviral therapy." Retrovirology 12, no. 1 (12, 2015):
1-17.
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