Molecular and cellular basis for transformation associated with BRCA1-haploinsufficiency.

Sedic, Maja.


  • Abstract: Individuals with inherited mutations in BRCA1 have a ~ 80% chance of developing breast and ovarian cancer within their lifetimes. Although BRCA1 function appears to be essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer development in individuals with mutations in BRCA1 is restricted to only a select few tissues. Moreover since loss o... read more
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